| I-75 runs north and south from Detroit to Miami. This stretch of highway serves as the main fairway for people commuting from the northern suburbs such as West Chester and Mason. |
| I-71 runs northeast and southwest connecting Colubus and Cleveland to Louisville. This highway is traveled by commuters mainly from the northeastern suburbs such as Blue Ash and Loveland. |
| I-275 the outer belt loop that encircles Greater Cincinnati, SE Indian, and Northern Kentucky. It is one of the longest beltways in the nation at 83 miles long. |
| I-471 runs from downtown to the eastern part of I-275 in northern Kentucky. This highway is mainly used from commuters from eastern Cincinnati and northern Kentucky. |
| I-74 connects northwest Cincinnati to Indianapolis. This highway is traveled by commuters from the western suburbs and SE Indiana. |
| Rte. 562 (Norwood Lateral) runs between I-75 and I-71. |
| Rte. 126 (Ronald Reagan Highway) provides and a shortcut running east-west inside the I-275 beltway. |
